Toward in vivo diagnosis of skin cancer using multimode imaging dermoscopy: (I) clinical system development and validation

Nicholas MacKinnon; Fartash Vasefi; Daniel L. Farkas

doi:10.1117/12.2041818

4 March 2014 Toward in vivo diagnosis of skin cancer using multimode imaging dermoscopy: (I) clinical system development and validation

Nicholas MacKinnon, Fartash Vasefi, Daniel L. Farkas

Author Affiliations +

Proceedings Volume 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII; 89470I (2014) https://doi.org/10.1117/12.2041818
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We introduce the new clinical prototype of SkinSpect – a multimode dermoscope combining fluorescence, polarization and hyperspectral imaging. The system determines relative melanin and hemoglobin concentrations as well as oxygen saturation while effectively correcting for the melanin-hemoglobin crosstalk commonly observed in other spectral dermoscopy approaches. Optical specifications and performance of this new clinical and our previous research prototypes are compared. Light source programming and image polarization selection using LCVR are optimized to improve the accuracy of skin chromophore quantitation. Polarized attenuation spectra are computed and applied to a Beer-Lambert linear model to extract the relative contributions of chromophores at every pixel.

Citation Download Citation

Nicholas MacKinnon, Fartash Vasefi, and Daniel L. Farkas "Toward in vivo diagnosis of skin cancer using multimode imaging dermoscopy: (I) clinical system development and validation", Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 89470I (4 March 2014); https://doi.org/10.1117/12.2041818

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