Hyperspectral imaging via spectral interferometric polarised coherent anti-Stokes Raman scattering

Brad Littleton; Thomas Kavanagh; Frederic Festy; David Richards

doi:10.1117/12.2040940

28 February 2014 Hyperspectral imaging via spectral interferometric polarised coherent anti-Stokes Raman scattering

Brad Littleton, Thomas Kavanagh, Frederic Festy, David Richards

Proceedings Volume 8948, Multiphoton Microscopy in the Biomedical Sciences XIV; 89482T (2014) https://doi.org/10.1117/12.2040940
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We have developed a new method for quantitative broadband CARS spectral imaging, which uses passive polarisation optics combined with spectrally-resolved balanced homodyne detection to remove the non-resonant background (NRB) in a single exposure. Independent measurement of the Stokes spectrum is not required for NRB removal, and the resulting spectra are amplified by the non-resonant response, vary linearly with concentration, and can be directly related to polarized spontaneous Raman spectra. The technique has relaxed requirements on spectral phase and instrument stability, is suitable for any laser system capable of generating CARS, and has been successfully applied to rapid hyperspectral Raman imaging.

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Brad Littleton, Thomas Kavanagh, Frederic Festy, and David Richards "Hyperspectral imaging via spectral interferometric polarised coherent anti-Stokes Raman scattering", Proc. SPIE 8948, Multiphoton Microscopy in the Biomedical Sciences XIV, 89482T (28 February 2014); https://doi.org/10.1117/12.2040940

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KEYWORDS

Hyperspectral imaging

CARS tomography

Interferometry

Imaging systems

Multiphoton microscopy

Raman spectroscopy

Signal to noise ratio

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