A laminar optical tomography system for the early cervical cancer diagnosis

Shanshan Cui; Mengyu Jia; Xueying Chen; Wei Meng; Feng Gao; Huijuan Zhao

doi:10.1117/12.2036527

4 March 2014 A laminar optical tomography system for the early cervical cancer diagnosis

Shanshan Cui, Mengyu Jia, Xueying Chen, Wei Meng, Feng Gao, Huijuan Zhao

Proceedings Volume 8952, Biomedical Applications of Light Scattering VIII; 895217 (2014) https://doi.org/10.1117/12.2036527
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Laminar optical tomography (LOT) is a new mesoscopic functional optical imaging technique, which is an extension of a confocal microscope and diffuse optical tomography to acquire both the coaxial and off-axis scattered light at the same time. In this paper, a LOT system with a larger detection area aiming at the in vivo detection of early cervical cancer is developed. The field of view of our system is 10 mm x 10 mm. In order to improve the image quality of the system, two methods were performed: the correction of image distortion and the restriction of returning light. The performance of the system with aperture stop was assessed by liquid phantom experiments. Comparing with the Monte Carlo simulation, the measurement results show that the average relative errors of eight different source-detector distances corresponding to 4 source points are lower than the errors of the system taking the frame of objective lens as the aperture stop by 5.7%， 4.8%，6.1%，6.1% respectively. Moreover, the experiment based on the phantom with specified structure and optical parameters to simulate the cervix demonstrates that the system perform well for the cervix measurement.

Citation Download Citation

Shanshan Cui, Mengyu Jia, Xueying Chen, Wei Meng, Feng Gao, and Huijuan Zhao "A laminar optical tomography system for the early cervical cancer diagnosis", Proc. SPIE 8952, Biomedical Applications of Light Scattering VIII, 895217 (4 March 2014); https://doi.org/10.1117/12.2036527

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