Multidentate oligomeric ligands to enhance the biocompatibility of iron oxide and other metal nanoparticles

Wentao Wang; Goutam Palui; Xin Ji; Fadi Aldeek; Hedi Mattoussi

doi:10.1117/12.2038307

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24 March 2014 Multidentate oligomeric ligands to enhance the biocompatibility of iron oxide and other metal nanoparticles

Wentao Wang, Goutam Palui, Xin Ji, Fadi Aldeek, Hedi Mattoussi

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Proceedings Volume 8955, Colloidal Nanoparticles for Biomedical Applications IX; 89550B (2014) https://doi.org/10.1117/12.2038307
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We prepared a set of multi-coordinating and reactive amphiphilic polymer ligands and used them for surface-functionalizing magnetic iron oxide nanoparticles. The amphiphilic oligomers were prepared by coupling (via one step nucleophilic addition) several dopamine anchoring groups, polyethylene glycol moieties and reactive groups onto a poly(isobutylene-alt-maleic anhydride) chain. The availability of several anchoring groups in the same ligand greatly enhances the ligand affinity to the nanoparticle surfaces, via multiplecoordination, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation to target biomolecules. The hydrophilic nanoparticles capped with these polymers maintain compact size and exhibit great long term colloidal stability.

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Wentao Wang, Goutam Palui, Xin Ji, Fadi Aldeek, and Hedi Mattoussi "Multidentate oligomeric ligands to enhance the biocompatibility of iron oxide and other metal nanoparticles", Proc. SPIE 8955, Colloidal Nanoparticles for Biomedical Applications IX, 89550B (24 March 2014); https://doi.org/10.1117/12.2038307

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