Challenges in resonant cavity biosensor design: collection efficiency and specificity

Andrea M. Armani; Simin Mehrabani; Victoria Sun; Samantha McBirney; Rasheeda M. Hawk; Eda Gungor; Michele Lee

doi:10.1117/12.2035555

4 March 2014 Challenges in resonant cavity biosensor design: collection efficiency and specificity

Andrea M. Armani, Simin Mehrabani, Victoria Sun, Samantha McBirney, Rasheeda M. Hawk, Eda Gungor, Michele Lee

Proceedings Volume 8960, Laser Resonators, Microresonators, and Beam Control XVI; 89600F (2014) https://doi.org/10.1117/12.2035555
Event: SPIE LASE, 2014, San Francisco, California, United States

Abstract

Optical cavities have successfully demonstrated the ability to detect a wide range of analytes with exquisite sensitivity. However, optimizing other parameters of the system, such as collection efficiency and specificity, have remained elusive. This presentation will discuss some of the recent work in this area, including 3D COMSOL Multiphysics models including mass transfer and binding kinetics of different cavity geometries and covalent attachment methods for a wide range of biological and synthetic moieties. A few representative experimental demonstrations will also be presented.

Citation Download Citation

Andrea M. Armani, Simin Mehrabani, Victoria Sun, Samantha McBirney, Rasheeda M. Hawk, Eda Gungor, and Michele Lee "Challenges in resonant cavity biosensor design: collection efficiency and specificity", Proc. SPIE 8960, Laser Resonators, Microresonators, and Beam Control XVI, 89600F (4 March 2014); https://doi.org/10.1117/12.2035555

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