Paper analytical devices for detection of low-quality pharmaceuticals

A. Weaver; M. Lieberman

doi:10.1117/12.2044776

6 March 2014 Paper analytical devices for detection of low-quality pharmaceuticals

A. Weaver, M. Lieberman

Proceedings Volume 8976, Microfluidics, BioMEMS, and Medical Microsystems XII; 89760H (2014) https://doi.org/10.1117/12.2044776
Event: SPIE MOEMS-MEMS, 2014, San Francisco, California, United States

Abstract

There is currently no global screening system to detect low quality pharmaceuticals, despite widespread recognition of the public health problems caused by substandard and falsified medicines. In order to fill this void, we designed a rapid field screening test that is interfaced with the mobile phone network. The user scrapes a pill over several reaction areas on a paper test card, and then dips one edge of the card into water to activate dried reagents stored on the paper. These reagents carry out multiple color tests and result in a pattern of colored stripes that give information about the chemical content of the pill. The test cards are inexpensive and instrument-free, and we think they will be a scalable testing option in low resource settings. Studies on falsified drugs archived at the FDA show that the test cards are effective at detecting a wide variety of low-quality formulations of many classes of pharmaceuticals, and field tests are currently under way in Kenya.

Citation Download Citation

A. Weaver and M. Lieberman "Paper analytical devices for detection of low-quality pharmaceuticals", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760H (6 March 2014); https://doi.org/10.1117/12.2044776

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