Terahertz polarization imaging for colon cancer detection

Pallavi Doradla; Karim Alavi; Cecil S. Joseph; Robert H. Giles

doi:10.1117/12.2038650

7 March 2014 Terahertz polarization imaging for colon cancer detection

Pallavi Doradla, Karim Alavi, Cecil S. Joseph, Robert H. Giles

Proceedings Volume 8985, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VII; 89850K (2014) https://doi.org/10.1117/12.2038650
Event: SPIE OPTO, 2014, San Francisco, California, United States

Abstract

Continuous wave terahertz (THz) imaging has the potential to offer a safe, noninvasive medical imaging modality for delineating colorectal cancer. The terahertz reflectance measurements of fresh 3 – 5 mm thick human colonic excisions were acquired using a continuous-wave polarization imaging technique. A CO₂ optically pumped Far- Infrared molecular gas laser operating at 584 GHz was used to illuminate the colon tissue, while the reflected signals were detected using a liquid Helium cooled silicon bolometer. Both co-polarized and cross-polarized remittance from the samples was collected using wire grid polarizers in the experiment. The experimental analysis of 2D images obtained from THz reflection polarization imaging techniques showed intrinsic contrast between cancerous and normal regions based on increased reflection from the tumor. Also, the study demonstrates that the cross-polarized terahertz images not only correlates better with the histology, but also provide consistent relative reflectance difference values between normal and cancerous regions for all the measured specimens.

Citation Download Citation

Pallavi Doradla, Karim Alavi, Cecil S. Joseph, and Robert H. Giles "Terahertz polarization imaging for colon cancer detection", Proc. SPIE 8985, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VII, 89850K (7 March 2014); https://doi.org/10.1117/12.2038650

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available