Shape-constrained multi-atlas segmentation of spleen in CT

Zhoubing Xu; Bo Li; Swetasudha Panda; Andrew J. Asman; Kristen L. Merkle; Peter L. Shanahan; Richard G. Abramson; Bennett A. Landman

doi:10.1117/12.2043079

21 March 2014 Shape-constrained multi-atlas segmentation of spleen in CT

Zhoubing Xu, Bo Li, Swetasudha Panda, Andrew J. Asman, Kristen L. Merkle, Peter L. Shanahan, Richard G. Abramson, Bennett A. Landman

Author Affiliations +

Proceedings Volume 9034, Medical Imaging 2014: Image Processing; 903446 (2014) https://doi.org/10.1117/12.2043079
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Spleen segmentation on clinically acquired CT data is a challenging problem given the complicity and variability of abdominal anatomy. Multi-atlas segmentation is a potential method for robust estimation of spleen segmentations, but can be negatively impacted by registration errors. Although labeled atlases explicitly capture information related to feasible organ shapes, multi-atlas methods have largely used this information implicitly through registration. We propose to integrate a level set shape model into the traditional label fusion framework to create a shape-constrained multi-atlas segmentation framework. Briefly, we (1) adapt two alternative atlas-to-target registrations to obtain the loose bounds on the inner and outer boundaries of the spleen shape, (2) project the fusion estimate to registered shape models, and (3) convert the projected shape into shape priors. With the constraint of the shape prior, our proposed method offers a statistically significant improvement in spleen labeling accuracy with an increase in DSC by 0.06, a decrease in symmetric mean surface distance by 4.01 mm, and a decrease in symmetric Hausdorff surface distance by 23.21 mm when compared to a locally weighted vote (LWV) method.

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Zhoubing Xu, Bo Li, Swetasudha Panda, Andrew J. Asman, Kristen L. Merkle, Peter L. Shanahan, Richard G. Abramson, and Bennett A. Landman "Shape-constrained multi-atlas segmentation of spleen in CT", Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 903446 (21 March 2014); https://doi.org/10.1117/12.2043079

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