Accurate discrimination of Alzheimer's disease from other dementia and/or normal subjects using SPECT specific volume analysis

Hitoshi Iyatomi; Jun Hashimoto; Fumuhito Yoshii; Toshiki Kazama; Shuichi Kawada; Yutaka Imai

doi:10.1117/12.2044011

24 March 2014 Accurate discrimination of Alzheimer's disease from other dementia and/or normal subjects using SPECT specific volume analysis

Hitoshi Iyatomi, Jun Hashimoto, Fumuhito Yoshii, Toshiki Kazama, Shuichi Kawada, Yutaka Imai

Author Affiliations +

Proceedings Volume 9035, Medical Imaging 2014: Computer-Aided Diagnosis; 903523 (2014) https://doi.org/10.1117/12.2044011
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Discrimination between Alzheimer’s disease and other dementia is clinically significant, however it is often difficult. In this study, we developed classification models among Alzheimer’s disease (AD), other dementia (OD) and/or normal subjects (NC) using patient factors and indices obtained by brain perfusion SPECT. SPECT is commonly used to assess cerebral blood flow (CBF) and allows the evaluation of the severity of hypoperfusion by introducing statistical parametric mapping (SPM). We investigated a total of 150 cases (50 cases each for AD, OD, and NC) from Tokai University Hospital, Japan. In each case, we obtained a total of 127 candidate parameters from: (A) 2 patient factors (age and sex), (B) 12 CBF parameters and 113 SPM parameters including (C) 3 from specific volume analysis (SVA), and (D) 110 from voxel-based analysis stereotactic extraction estimation (vbSEE). We built linear classifiers with a statistical stepwise feature selection and evaluated the performance with the leave-one-out cross validation strategy. Our classifiers achieved very high classification performances with reasonable number of selected parameters. In the most significant discrimination in clinical, namely those of AD from OD, our classifier achieved both sensitivity (SE) and specificity (SP) of 96%. In a similar way, our classifiers achieved a SE of 90% and a SP of 98% in AD from NC, as well as a SE of 88% and a SP of 86% in AD from OD and NC cases. Introducing SPM indices such as SVA and vbSEE, classification performances improved around 7-15%. We confirmed that these SPM factors are quite important for diagnosing Alzheimer’s disease.

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Hitoshi Iyatomi, Jun Hashimoto, Fumuhito Yoshii, Toshiki Kazama, Shuichi Kawada, and Yutaka Imai "Accurate discrimination of Alzheimer's disease from other dementia and/or normal subjects using SPECT specific volume analysis", Proc. SPIE 9035, Medical Imaging 2014: Computer-Aided Diagnosis, 903523 (24 March 2014); https://doi.org/10.1117/12.2044011

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KEYWORDS

Alzheimer's disease

Single photon emission computed tomography

Dementia

Surface plasmons

Scanning probe microscopy

Brain

Statistical analysis

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