Quantitative characterization of brain β-amyloid using a joint PiB/FDG PET image histogram

Jon J. Camp; Dennis P. Hanson; David R. Holmes III; Bradley J. Kemp; Matthew L. Senjem; Melissa E. Murray; Dennis W. Dickson; Joseph Parisi; Ronald C. Petersen; Val J. Lowe; Richard A. Robb

doi:10.1117/12.2042880

24 March 2014 Quantitative characterization of brain β-amyloid using a joint PiB/FDG PET image histogram

Jon J. Camp, Dennis P. Hanson, David R. Holmes III, Bradley J. Kemp, Matthew L. Senjem, Melissa E. Murray, Dennis W. Dickson, Joseph Parisi, Ronald C. Petersen, Val J. Lowe, Richard A. Robb

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Proceedings Volume 9035, Medical Imaging 2014: Computer-Aided Diagnosis; 90352A (2014) https://doi.org/10.1117/12.2042880
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

A complex analysis performed by spatial registration of PiB and MRI patient images in order to localize the PiB signal to specific cortical brain regions has been proven effective in identifying imaging characteristics associated with underlying Alzheimer’s Disease (AD) and Lewy Body Disease (LBD) pathology. This paper presents an original method of image analysis and stratification of amyloid-related brain disease based on the global spatial correlation of PiB PET images with ¹⁸F-FDG PET images (without MR images) to categorize the PiB signal arising from the cortex. Rigid registration of PiB and ¹⁸F-FDG images is relatively straightforward, and in registration the ¹⁸F-FDG signal serves to identify the cortical region in which the PiB signal is relevant. Cortical grey matter demonstrates the highest levels of amyloid accumulation and therefore the greatest PiB signal related to amyloid pathology. The highest intensity voxels in the ¹⁸F-FDG image are attributed to the cortical grey matter. The correlation of the highest intensity PiB voxels with the highest 18F-FDG values indicates the presence of β-amyloid protein in the cortex in disease states, while correlation of the highest intensity PiB voxels with mid-range ¹⁸F-FDG values indicates only nonspecific binding in the white matter.

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Jon J. Camp, Dennis P. Hanson, David R. Holmes III, Bradley J. Kemp, Matthew L. Senjem, Melissa E. Murray, Dennis W. Dickson, Joseph Parisi, Ronald C. Petersen, Val J. Lowe, and Richard A. Robb "Quantitative characterization of brain β-amyloid using a joint PiB/FDG PET image histogram", Proc. SPIE 9035, Medical Imaging 2014: Computer-Aided Diagnosis, 90352A (24 March 2014); https://doi.org/10.1117/12.2042880

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KEYWORDS

Positron emission tomography

Brain

Image registration

Neuroimaging

Magnetic resonance imaging

Pathology

Diagnostics

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