A dimensionless dynamic contrast enhanced MRI parameter for intra-prostatic tumour target volume delineation: initial comparison with histology

W. Thomas Hrinivich; Eli Gibson; Mena Gaed; Jose A. Gomez; Madeleine Moussa; Charles A. McKenzie; Glenn S. Bauman; Aaron D. Ward; Aaron Fenster; Eugene Wong

doi:10.1117/12.2043593

12 March 2014 A dimensionless dynamic contrast enhanced MRI parameter for intra-prostatic tumour target volume delineation: initial comparison with histology

W. Thomas Hrinivich, Eli Gibson, Mena Gaed, Jose A. Gomez, Madeleine Moussa, Charles A. McKenzie, Glenn S. Bauman, Aaron D. Ward, Aaron Fenster, Eugene Wong

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Proceedings Volume 9036, Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling; 90362I (2014) https://doi.org/10.1117/12.2043593
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Purpose: T2 weighted and diffusion weighted magnetic resonance imaging (MRI) show promise in isolating prostate tumours. Dynamic contrast enhanced (DCE)-MRI has also been employed as a component in multi-parametric tumour detection schemes. Model-based parameters such as K^trans are conventionally used to characterize DCE images and require arterial contrast agent (CR) concentration. A robust parameter map that does not depend on arterial input may be more useful for target volume delineation. We present a dimensionless parameter (W_io) that characterizes CR wash-in and washout rates without requiring arterial CR concentration. W_io is compared to K^trans in terms of ability to discriminate cancer in the prostate, as demonstrated via comparison with histology. Methods: Three subjects underwent DCE-MRI using gadolinium contrast and 7 s imaging temporal resolution. A pathologist identified cancer on whole-mount histology specimens, and slides were deformably registered to MR images. The ability of W_io maps to discriminate cancer was determined through receiver operating characteristic curve (ROC) analysis. Results: There is a trend that W_io shows greater area under the ROC curve (AUC) than K^trans with median AUC values of 0.74 and 0.69 respectively, but the difference was not statistically significant based on a Wilcoxon signed-rank test (p = 0.13). Conclusions: Preliminary results indicate that W_io shows potential as a tool for K^trans QA, showing similar ability to discriminate cancer in the prostate as K^trans without requiring arterial CR concentration.

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W. Thomas Hrinivich, Eli Gibson, Mena Gaed, Jose A. Gomez, Madeleine Moussa, Charles A. McKenzie, Glenn S. Bauman, Aaron D. Ward, Aaron Fenster, and Eugene Wong "A dimensionless dynamic contrast enhanced MRI parameter for intra-prostatic tumour target volume delineation: initial comparison with histology", Proc. SPIE 9036, Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling, 90362I (12 March 2014); https://doi.org/10.1117/12.2043593

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