Fractal anisotropy in tissue refractive index fluctuations: potential role in precancer detection

Nandan Kumar Das; Subhasri Chatterjee; Semanti Chakraborty; P. K. Panigrahi; A. Pradhan; N. Ghosh

doi:10.1117/12.2051964

8 May 2014 Fractal anisotropy in tissue refractive index fluctuations: potential role in precancer detection

Nandan Kumar Das, Subhasri Chatterjee, Semanti Chakraborty, P. K. Panigrahi, A. Pradhan, N. Ghosh

Proceedings Volume 9129, Biophotonics: Photonic Solutions for Better Health Care IV; 91290V (2014) https://doi.org/10.1117/12.2051964
Event: SPIE Photonics Europe, 2014, Brussels, Belgium

Abstract

Differential interference contrast images (DIC) are the direct representation of the refractive index fluctuations of human cervical tissues. These refractive index fluctuations are known to follow self-similar behaviour and in general are multifractal in nature. In this present study, multifractal detrended fluctuation analysis (MFDFA) on refractive index fluctuations from DIC images has been performed by unfolding the tissue-images horizontally and vertically. Our analysis clearly shows that refractive index fluctuations of human cervical tissues are anisotropic-fractal in nature and anisotropy reduced as cancer progress.

Citation Download Citation

Nandan Kumar Das, Subhasri Chatterjee, Semanti Chakraborty, P. K. Panigrahi, A. Pradhan, and N. Ghosh "Fractal anisotropy in tissue refractive index fluctuations: potential role in precancer detection", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91290V (8 May 2014); https://doi.org/10.1117/12.2051964

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