Polarimetric fiber grating biosensor for in-situ high-sensitive intracellular density measurement

Tuan Guo; Fu Liu; Yu Liu; Nan-Kuang Chen; Bai-Ou Guan; Jacques Albert

doi:10.1117/12.2058465

2 June 2014 Polarimetric fiber grating biosensor for in-situ high-sensitive intracellular density measurement

Tuan Guo, Fu Liu, Yu Liu, Nan-Kuang Chen, Bai-Ou Guan, Jacques Albert

Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 915746 (2014) https://doi.org/10.1117/12.2058465
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain

Abstract

High sensitivity biological sample measurements have been achieved by using a 12o tilted fiber Bragg grating (TFBG). Human acute leukemia cells with different intracellular densities and refractive index (RI) ranging from 1.3342 to 1.3344 were clearly discriminated in-situ by using the differential transmission spectrum between two orthogonal polarizations for the last guided mode resonance before “cut-off”, with an amplitude variation sensitivity of 1.8×10⁴ dB/RIU and a limit of detection of 2×10^-5RIU. The technique is inherently temperature-insensitive.

Citation Download Citation

Tuan Guo, Fu Liu, Yu Liu, Nan-Kuang Chen, Bai-Ou Guan, and Jacques Albert "Polarimetric fiber grating biosensor for in-situ high-sensitive intracellular density measurement", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 915746 (2 June 2014); https://doi.org/10.1117/12.2058465

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