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2 June 2014 UV resonance Raman sensing of pharmaceutical drugs in hollow fibers
D. Yan, J. Popp, T. Frosch
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Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 915755 (2014) https://doi.org/10.1117/12.2059574
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain
Abstract
We report about the experimental combination of UV resonance Raman sensing (UV-RRS) and fiber enhanced Raman sensing (FERS) on pharmaceuticals. The results show that the chemical sensitivity is highly improved and at the same time the sample volume is reduced compared to conventional measurements. A hundreds-fold improvement of the limit of detection (LOD) has been achieved with the combination of resonance Raman enhancement and fiber enhancement. The enhanced Raman signal has a reliable linear relationship with the concentration of the analyte, and therefore shows great potential for quantitative analysis of pharmaceuticals.
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D. Yan, J. Popp, and T. Frosch "UV resonance Raman sensing of pharmaceutical drugs in hollow fibers", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 915755 (2 June 2014); https://doi.org/10.1117/12.2059574
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KEYWORDS
Raman spectroscopy
Resonance enhancement
Optical fibers
Ultraviolet radiation
Liquids
Fiber lasers
Signal to noise ratio
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