Tumors in murine brains studied by grating-based phase contrast microtomography

Georg Schulz; Marco Dominietto; Zsofia Kovacs; Rüdiger Schmitz; Simone E. Hieber; Peter Thalmann; Felix Beckmann; Bert Müller

doi:10.1117/12.2060544

12 September 2014 Tumors in murine brains studied by grating-based phase contrast microtomography

Georg Schulz, Marco Dominietto, Zsofia Kovacs, Rüdiger Schmitz, Simone E. Hieber, Peter Thalmann, Felix Beckmann, Bert Müller

Author Affiliations +

Proceedings Volume 9212, Developments in X-Ray Tomography IX; 92120Q (2014) https://doi.org/10.1117/12.2060544
Event: SPIE Optical Engineering + Applications, 2014, San Diego, California, United States

Abstract

Angiogenesis, i.e. the formation of vessels, is one of the key processes during tumor development. The newly formed vessels transport oxygen and nutrients from the healthy tissue to the tumor and gives tumor cells the possibility to replicate. The principle of anti-angiogenic therapy is to block angiogenic process in order to stop tumor growth. The aim of the present study is the investigation of murine glioma vascular architecture at early (7 days), intermediate (10 and 15 days) and late (23 days) stage of growth by means of grating-based phase contrast microtomography. We demonstrate that this technique yields premium contrast between healthy and cancerous parts of murine brain tissues.

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Georg Schulz, Marco Dominietto, Zsofia Kovacs, Rüdiger Schmitz, Simone E. Hieber, Peter Thalmann, Felix Beckmann, and Bert Müller "Tumors in murine brains studied by grating-based phase contrast microtomography", Proc. SPIE 9212, Developments in X-Ray Tomography IX, 92120Q (12 September 2014); https://doi.org/10.1117/12.2060544

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