Evaluation of neural cochlear structures after noise trauma using x-ray tomography

Claus-Peter Richter; Whitney Liddy; Amanda Vo; Hunter Young; Stuart Stock; Xianghui Xiao; Donna Whitlon

doi:10.1117/12.2062385

11 September 2014 Evaluation of neural cochlear structures after noise trauma using x-ray tomography

Claus-Peter Richter, Whitney Liddy, Amanda Vo, Hunter Young, Stuart Stock, Xianghui Xiao, Donna Whitlon

Author Affiliations +

Proceedings Volume 9212, Developments in X-Ray Tomography IX; 92120U (2014) https://doi.org/10.1117/12.2062385
Event: SPIE Optical Engineering + Applications, 2014, San Diego, California, United States

Abstract

According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.

Citation Download Citation

Claus-Peter Richter, Whitney Liddy, Amanda Vo, Hunter Young, Stuart Stock, Xianghui Xiao, and Donna Whitlon "Evaluation of neural cochlear structures after noise trauma using x-ray tomography", Proc. SPIE 9212, Developments in X-Ray Tomography IX, 92120U (11 September 2014); https://doi.org/10.1117/12.2062385

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE