Investigation of thermal denaturation of solid oxytocin by terahertz dielectric spectroscopy

Xiangjun Li; Xiaojie Yang; Jianjun Liu; Yong Du; Zhi Hong

doi:10.1117/12.2065231

21 August 2014 Investigation of thermal denaturation of solid oxytocin by terahertz dielectric spectroscopy

Xiangjun Li, Xiaojie Yang, Jianjun Liu, Yong Du, Zhi Hong

Proceedings Volume 9233, International Symposium on Photonics and Optoelectronics 2014; 92330S (2014) https://doi.org/10.1117/12.2065231
Event: International Symposium on Photonics and Optoelectronics (SOPO 2014), 2014, Suzhou, China

Abstract

We investigate the thermal denaturation of solid oxytocin using terahertz time domain spectroscopy(THz-TDS). When the peptide is heated up from 25°C to 107°C and cooled down to 25°C again, an irreversible decrease in its THz absorption coefficient and refractive index is observed. The corresponding frequency-dependent permittivity during heating is fitted by the Debye model with single relaxation time. The relaxation times during temperature rising agree very well with Arrhenius equation with the activation energy of 3.12kJ/(K•mol) as an indicator for its thermal denaturation difficulty.

Citation Download Citation

Xiangjun Li, Xiaojie Yang, Jianjun Liu, Yong Du, and Zhi Hong "Investigation of thermal denaturation of solid oxytocin by terahertz dielectric spectroscopy", Proc. SPIE 9233, International Symposium on Photonics and Optoelectronics 2014, 92330S (21 August 2014); https://doi.org/10.1117/12.2065231

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