Mueller-matrix imaging of laser autofluorescence of biological tissues

L. I. Trifoniuk; A. G. Ushenko; O. V. Dubolazov; A. O. Gritsyuk; A. O. Karachevtsev; M. Sidor

doi:10.1117/12.2072264

20 February 2015 Mueller-matrix imaging of laser autofluorescence of biological tissues

L. I. Trifoniuk, A. G. Ushenko, O. V. Dubolazov, A. O. Gritsyuk, A. O. Karachevtsev, M. Sidor

Proceedings Volume 9258, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VII; 925815 (2015) https://doi.org/10.1117/12.2072264
Event: Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies 2014, 2014, Constanta, Romania

Abstract

The work consists of investigation results of diagnostic efficiency of a new azimuthally stable Muellermatrix method of analysis of laser autofluorescence coordinate distributions of biological tissues histological sections. A new model of generalized optical anisotropy of biological tissues protein networks is proposed in order to define the processes of laser autofluorescence. The influence of complex mechanisms of both phase anisotropy (linear birefringence and optical activity) and linear (circular) dichroism is taken into account. The interconnections between the azimuthally stable Mueller-matrix elements characterizing laser autofluorescence and different mechanisms of optical anisotropy are determined. The statistic analysis of coordinate distributions of such Mueller-matrix rotation invariants is proposed. Thereupon the quantitative criteria (statistic moments of the 1st to the 4th order) of differentiation of histological sections of myometrium – group 1 (fibromyoma) and group 2 (adenocarcinoma) are estimated.

Citation Download Citation

L. I. Trifoniuk, A. G. Ushenko, O. V. Dubolazov, A. O. Gritsyuk, A. O. Karachevtsev, and M. Sidor "Mueller-matrix imaging of laser autofluorescence of biological tissues", Proc. SPIE 9258, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies VII, 925815 (20 February 2015); https://doi.org/10.1117/12.2072264

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available