Optical functional imaging of retina using stimulus-evoked intrinsic optical signals

Yuhong Yang; Shuangyun Shao; Bei Tian; Xueqian Guo

doi:10.1117/12.2073567

20 November 2014 Optical functional imaging of retina using stimulus-evoked intrinsic optical signals

Yuhong Yang, Shuangyun Shao, Bei Tian, Xueqian Guo

Proceedings Volume 9268, Optics in Health Care and Biomedical Optics VI; 92682N (2014) https://doi.org/10.1117/12.2073567
Event: SPIE/COS Photonics Asia, 2014, Beijing, China

Abstract

Without dying and fluorescently labeled markers on tissues, Intrinsic optical signals (IOSs) detection technology is a promising method to detect retinal function without influence on normal activities of organism. Slow IOSs of retina reflect the activities in inner retina and the middle layer of retina. In this paper, an IOSs’ detection system was built to detect slow IOSs based clinical instrument, Heidelberg Retina Angiograph 2(HAR2). The retina was illuminated by near infrared light continuously during the experiments. The visible light was presented to stimulate the retina. After image alignment and image processing, the signal-to-noise ratio of the IOSs was improved and the signal changes can be extracted. The experimental results showed that the present detection system is suitable to obtain the slow IOSs in clinic and IOSs detection technology is an effective noninvasive method to study changes of function of retina.

Citation Download Citation

Yuhong Yang, Shuangyun Shao, Bei Tian, and Xueqian Guo "Optical functional imaging of retina using stimulus-evoked intrinsic optical signals", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92682N (20 November 2014); https://doi.org/10.1117/12.2073567

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available