Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies

Henry Hirschberg M.D.; Anthony Trinidad; Catherine E. Christie M.D.; Qian Peng M.D.; Young J. Kwon; Steen Madsen III

doi:10.1117/12.2082850

26 February 2015 Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies

Henry Hirschberg M.D., Anthony Trinidad, Catherine E. Christie M.D., Qian Peng M.D., Young J. Kwon, Steen Madsen III

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 930322 (2015) https://doi.org/10.1117/12.2082850
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Macrophages loaded with gold nanoshells (AuNS), that convert near infrared light to heat, can be used as transport vectors for photothermal hyperthermia of tumors. The purpose of this study was to investigate the effects of combined macrophage mediated photothermal therapy (PTT) and PDT on head and neck squamous cell carcinoma (HNSCC). The results provide proof of concept for the use of macrophages as a delivery vector of AuNS for photothermal enhancement of the effects of PDT on squamous cell carcinoma. A significant synergy was demonstrated with combined PDT and PTT compared to each modality applied separately.

Citation Download Citation

Henry Hirschberg M.D., Anthony Trinidad, Catherine E. Christie M.D., Qian Peng M.D., Young J. Kwon, and Steen Madsen III "Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 930322 (26 February 2015); https://doi.org/10.1117/12.2082850

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