Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer

Kan Lin; Jianfeng Wang; Mads Sylvest Bergholt; Wei Zheng; Hongzhi Xu; Jian-lin Ren; Khek Yu Ho; Ming Teh; Khay Guan Yeoh; Zhiwei Huang

doi:10.1117/12.2080851

2 March 2015 Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer

Kan Lin, Jianfeng Wang, Mads Sylvest Bergholt, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Author Affiliations +

Proceedings Volume 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II; 93040V (2015) https://doi.org/10.1117/12.2080851
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

This work aims to apply a fiber-optic Raman spectroscopy technique for in vivo assessment of adenomatous polyps during clinical colonoscopy. We have developed a fiber-optic Raman endoscopic technique capable of simultaneously acquiring both the fingerprint (FP) (i.e., 800–1800 cm^-1) and high-wavenumber (HW) (i.e., 2800–3600 cm^-1) Raman spectra for real-time assessment of colorectal carcinogenesis. Simultaneous FP/HW Raman endoscopy provides a diagnostic sensitivity of 90.9% and specificity of 83.3% for differentiating adenoma from hyperplastic polyps, which is superior to either the FP or HW Raman technique alone. This study shows that simultaneous FP/HW Raman spectroscopy has the potential for improving early diagnosis of adenomatous polyps in vivo during colonoscopic examination.

Citation Download Citation

Kan Lin, Jianfeng Wang, Mads Sylvest Bergholt, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, and Zhiwei Huang "Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer", Proc. SPIE 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II, 93040V (2 March 2015); https://doi.org/10.1117/12.2080851

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