Characterization of rare-earth-doped nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams

Arash Darafsheh; Stan Najmr; Taejong Paik; Michael E. Tenuto; Christopher B. Murray; Jarod C. Finlay; Joseph S. Friedberg

doi:10.1117/12.2079373

2 March 2015 Characterization of rare-earth-doped nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams

Arash Darafsheh, Stan Najmr, Taejong Paik, Michael E. Tenuto, Christopher B. Murray, Jarod C. Finlay, Joseph S. Friedberg

Author Affiliations +

Proceedings Volume 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV; 930812 (2015) https://doi.org/10.1117/12.2079373
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We investigated the optical properties of novel terbium (Tb³⁺)-doped nanophosphors with various host compounds irradiated by clinical electron, photon, and proton beams for their potential as optical probes. The emission spectra of nanophosphors embedded in tissue-mimicking phantoms were collected by an optical fiber connected to a CCD-coupled spectrograph while the samples were irradiated with electron and photon beams generated by a medical linear accelerator and proton beams generated by a clinical cyclotron. We characterized the luminescence of such nanophosphors as a function of the beam energy and observed a dose dependency of the luminescence signal. We demonstrated x-ray luminescence, cathodoluminescence, and ionoluminescence of the nanophosphors in clinical ionizing radiation fields, which indicates their potential as downconverters of high-energy radiation into visible light.

Citation Download Citation

Arash Darafsheh, Stan Najmr, Taejong Paik, Michael E. Tenuto, Christopher B. Murray, Jarod C. Finlay, and Joseph S. Friedberg "Characterization of rare-earth-doped nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams", Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 930812 (2 March 2015); https://doi.org/10.1117/12.2079373

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