Plasmonic nanoparticle interaction with cell membrane for diagnostic applications

Sumana Das; Akshata Arikady; Ramakrishna Vasireddi; Krishna Harika; Manish Konnur; Gopalkrishna M. Hegde; D. Roy Mahapatra

doi:10.1117/12.2082598

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2 March 2015 Plasmonic nanoparticle interaction with cell membrane for diagnostic applications

Sumana Das, Akshata Arikady, Ramakrishna Vasireddi, Krishna Harika, Manish Konnur, Gopalkrishna M. Hegde, D. Roy Mahapatra

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Proceedings Volume 9310, Frontiers in Biological Detection: From Nanosensors to Systems VII; 93100A (2015) https://doi.org/10.1117/12.2082598
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Optofluidic schemes of inhibition, transport and activation by carrier molecules through cell membrane have interesting applications. Through plasmonic excitation of nanoparticles integrated in microfluidic channel, we observe cell membrane structural changes. Related phenomena are studied in situ in a microfluidic channel via fluorescence imaging. Detailed analysis is carried out to understand the possible application of this scheme in optically induced transport and expression of cell membrane protein. Optical properties of the cells undergoing plasmonic transport are monitored and correlated to cell expression assay. Plasmonic charge transport and optical transmission are measured in the microfluidic lab-on-chip along with in-situ imaging.

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Sumana Das, Akshata Arikady, Ramakrishna Vasireddi, Krishna Harika, Manish Konnur, Gopalkrishna M. Hegde, and D. Roy Mahapatra "Plasmonic nanoparticle interaction with cell membrane for diagnostic applications", Proc. SPIE 9310, Frontiers in Biological Detection: From Nanosensors to Systems VII, 93100A (2 March 2015); https://doi.org/10.1117/12.2082598

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