Probing myocardium biomechanics using quantitative optical coherence elastography

Shang Wang; Andrew L. Lopez III; Yuka Morikawa; Ge Tao; Jiasong Li; Irina V. Larina; James F. Martin; Kirill V. Larin

doi:10.1117/12.2078390

2 March 2015 Probing myocardium biomechanics using quantitative optical coherence elastography

Shang Wang, Andrew L. Lopez III, Yuka Morikawa, Ge Tao, Jiasong Li, Irina V. Larina, James F. Martin, Kirill V. Larin

Proceedings Volume 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX; 93121Z (2015) https://doi.org/10.1117/12.2078390
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We present a quantitative optical coherence elastographic method for noncontact assessment of the myocardium elasticity. The method is based on shear wave imaging optical coherence tomography (SWI-OCT), where a focused air-puff system is used to induce localized tissue deformation through a low-pressure short-duration air stream and a phase-sensitive OCT system is utilized to monitor the propagation of the induced tissue displacement with nanoscale sensitivity. The 1-D scanning of M-mode OCT imaging and the application of optical phase retrieval and mapping techniques enable the reconstruction and visualization of 2-D depth-resolved shear wave propagation in tissue with ultra-high frame rate. The feasibility of this method in quantitative elasticity measurement is demonstrated on tissue-mimicking phantoms with the estimated Young’s modulus compared with uniaxial compression tests. We also performed pilot experiments on ex vivo mouse cardiac muscle tissues with normal and genetically altered cardiomyocytes. Our results indicate this noncontact quantitative optical coherence elastographic method can be a useful tool for the cardiac muscle research and studies.

Citation Download Citation

Shang Wang, Andrew L. Lopez III, Yuka Morikawa, Ge Tao, Jiasong Li, Irina V. Larina, James F. Martin, and Kirill V. Larin "Probing myocardium biomechanics using quantitative optical coherence elastography", Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 93121Z (2 March 2015); https://doi.org/10.1117/12.2078390

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available