Progress on developing wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice

Azhar Zam; Pengfei Zhang; Yifan Jian; Marinko V. Sarunic; Stefano Bonora; Edward N. Pugh Jr.; Robert J. Zawadzki

doi:10.1117/12.2077867

16 March 2015 Progress on developing wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice

Azhar Zam, Pengfei Zhang, Yifan Jian, Marinko V. Sarunic, Stefano Bonora, Edward N. Pugh Jr., Robert J. Zawadzki

Author Affiliations +

Proceedings Volume 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX; 93122I (2015) https://doi.org/10.1117/12.2077867
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We present a new design for a wavefront sensorless adaptive optics (WS-AO) Fourier domain optical coherence tomography (FD-OCT) system for small animal retinal imaging in vivo. Without the optical complications necessary for inclusion of a wavefront sensor in the optical system, this version of WS-AO FD-OCT system has a simplified optical design, including elimination of long focal length scanning optics and optical conjugation of vertical and horizontal scanners. This modification provides a modular large Field of View for retinal screening (25 degree visual angle), while also allowing a “zoom” capability for allocating all the scanning resources to a smaller region of interest, allowing high resolution aberration-corrected imaging. In the present system we used a 0 Dpt contact lens to stabilize the mouse eye position and to allow long duration imaging. Defocus (axial focus position) in our system is controlled by the collimation of the OCT sample arm entrance beam.

Citation Download Citation

Azhar Zam, Pengfei Zhang, Yifan Jian, Marinko V. Sarunic, Stefano Bonora, Edward N. Pugh Jr., and Robert J. Zawadzki "Progress on developing wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice", Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 93122I (16 March 2015); https://doi.org/10.1117/12.2077867

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