Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma

Barry Vuong; Patryk Skowron; Tim-Rasmus Kiehl M.D.; Matthew Kyan; Livia Garzia; Helen Genis; Cuiru Sun; Michael D. Taylor M.D.; Victor X. D. Yang M.D.

doi:10.1117/12.2080642

2 March 2015 Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma

Barry Vuong, Patryk Skowron, Tim-Rasmus Kiehl M.D., Matthew Kyan, Livia Garzia, Helen Genis, Cuiru Sun, Michael D. Taylor M.D., Victor X. D. Yang M.D.

Author Affiliations +

Proceedings Volume 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX; 93122Z (2015) https://doi.org/10.1117/12.2080642
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

The hemodynamic environment is known to play a crucial role in the progression, rupture, and treatment of intracranial aneurysms. Currently there is difficulty assessing and measuring blood flow profiles in vivo. An emerging high resolution imaging modality known as split spectrum Doppler optical coherence tomography (ssDOCT) has demonstrated the capability to quantify hemodynamic patterns as well as arterial microstructural changes. In this study, we present a novel in vitro method to acquire precise blood flow patterns within a patient- specific aneurysm silicone flow models using ssDOCT imaging. Computational fluid dynamics (CFD) models were generated to verify ssDOCT results.

Citation Download Citation

Barry Vuong, Patryk Skowron, Tim-Rasmus Kiehl M.D., Matthew Kyan, Livia Garzia, Helen Genis, Cuiru Sun, Michael D. Taylor M.D., and Victor X. D. Yang M.D. "Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma", Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 93122Z (2 March 2015); https://doi.org/10.1117/12.2080642

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