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2 March 2015 Lateral resolution enhancement via imbricated spectral domain optical coherence tomography in a maximum-a-posterior reconstruction framework
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Abstract
The lateral resolution of a Spectral Domain Optical Coherence Tomography (SD-OCT) image is limited by the focusing properties of the OCT imaging probe optics, the wavelength range which SD-OCT system operates at, spherical and chromatic aberrations induced by the imaging optics, the optical properties of the imaged object, and in the special case of in-vivo retinal imaging by the optics of the eye. This limitation often results in challenges with resolving fine details and structures of the imaged sample outside of the Depth-Of-Focus (DOF) range. We propose a novel technique for generating Laterally Resolved OCT (LR-OCT) images using OCT measurements acquired with intentional imbrications. The proposed, novel method is based on a Maximum A Posteriori (MAP) reconstruction framework which takes advantage of a Stochastic Fully Connected Conditional Random Field (SFCRF) model to compensate for the artifacts and noise when reconstructing a LR-OCT image from imbricated OCT measurement. The proposed lateral resolution enhancement method was tested on synthetic OCT measurement as well as on a human cornea SDOCT image to evaluate the usefulness of the proposed approach in lateral resolution enhancement. Experimental results show that applying this method to OCT images, noticeably improves the sharpness of morphological features in the OCT image and in lateral direction, thus demonstrating better delineation of fine dot shape details in the synthetic OCT test, as well as better delineation of the keratocyte cells in the human corneal OCT test image.
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A. Boroomand, M. J. Shafiee, A. Wong, and K. Bizheva "Lateral resolution enhancement via imbricated spectral domain optical coherence tomography in a maximum-a-posterior reconstruction framework", Proc. SPIE 9312, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, 931240 (2 March 2015); https://doi.org/10.1117/12.2081494
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