Validity of blood flow measurement using 320 multi-detectors CT and first-pass distribution theory: a phantom study

Jun Chen; Xuefang Yu; Shaopeng Xu; Kenneth J. Zhou

doi:10.1117/12.2081312

11 March 2015 Validity of blood flow measurement using 320 multi-detectors CT and first-pass distribution theory: a phantom study

Jun Chen, Xuefang Yu, Shaopeng Xu, Kenneth J. Zhou

Author Affiliations +

Proceedings Volume 9315, Design and Quality for Biomedical Technologies VIII; 93150U (2015) https://doi.org/10.1117/12.2081312
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

To evaluate the feasibility of measuring the myocardial blood flow using 320 row detector CT by first-pass technique. Heart was simulated with a container that was filled with pipeline of 3mm diameter; coronary artery was simulated with a pipeline of 2 cm diameter and connected with the simulated heart. The simulated coronary artery was connected with a big container with 1500 ml saline and 150ml contrast agent. One pump linking with simulated heart will withdraw with a speed of 10 ml/min, 15 ml/min, 20 ml/min, 25 ml/min and 30 ml/min. First CT scan starts after 30 s of pumpback with certain speed. The second CT scan starts 5 s after first CT scans. CT images processed as follows: The second CT scan images subtract first CT scan images, calculate the increase of CT value of simulated heart and the CT value of the unit volume of simulated coronary artery and then to calculate the total inflow of myocardial blood flow. CT myocardial blood flows were calculated as: 0.94 ml/s, 2.09 ml/s, 2.74 ml/s, 4.18 ml/s, 4.86 ml/s. The correlation coefficient is 0.994 and r² = 0.97. The method of measuring the myocardial blood flow using 320 row detector CT by 2 scans is feasible. It is possible to develop a new method for quantitatively and functional assessment of myocardial perfusion blood flow with less radiation does.

Citation Download Citation

Jun Chen, Xuefang Yu, Shaopeng Xu, and Kenneth J. Zhou "Validity of blood flow measurement using 320 multi-detectors CT and first-pass distribution theory: a phantom study", Proc. SPIE 9315, Design and Quality for Biomedical Technologies VIII, 93150U (11 March 2015); https://doi.org/10.1117/12.2081312

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