Photoacoustic tomography guided diffuse optical tomography for small-animal model

Yihan Wang; Feng Gao; Wenbo Wan; Yan Zhang; Jiao Li

doi:10.1117/12.2075890

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5 March 2015 Photoacoustic tomography guided diffuse optical tomography for small-animal model

Yihan Wang, Feng Gao, Wenbo Wan, Yan Zhang, Jiao Li

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Proceedings Volume 9316, Multimodal Biomedical Imaging X; 93160P (2015) https://doi.org/10.1117/12.2075890
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Diffuse optical tomography (DOT) is a biomedical imaging technology for noninvasive visualization of spatial variation about the optical properties of tissue, which can be applied to in vivo small-animal disease model. However, traditional DOT suffers low spatial resolution due to tissue scattering. To overcome this intrinsic shortcoming, multi-modal approaches that incorporate DOT with other imaging techniques have been intensively investigated, where a priori information provided by the other modalities is normally used to reasonably regularize the inverse problem of DOT. Nevertheless, these approaches usually consider the anatomical structure, which is different from the optical structure. Photoacoustic tomography (PAT) is an emerging imaging modality that is particularly useful for visualizing lightabsorbing structures embedded in soft tissue with higher spatial resolution compared with pure optical imaging. Thus, we present a PAT-guided DOT approach, to obtain the location a priori information of optical structure provided by PAT first, and then guide DOT to reconstruct the optical parameters quantitatively. The results of reconstruction of phantom experiments demonstrate that both quantification and spatial resolution of DOT could be highly improved by the regularization of feasible-region information provided by PAT.

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Yihan Wang, Feng Gao, Wenbo Wan, Yan Zhang, and Jiao Li "Photoacoustic tomography guided diffuse optical tomography for small-animal model", Proc. SPIE 9316, Multimodal Biomedical Imaging X, 93160P (5 March 2015); https://doi.org/10.1117/12.2075890

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