In vivo melanoma depth detection by a handheld photoacoustic microscope

Yong Zhou; Wenxin Xing; Konstantin I. Maslov; Lynn A. Cornelius; Lihong V. Wang

doi:10.1117/12.2076684

11 March 2015 In vivo melanoma depth detection by a handheld photoacoustic microscope

Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, Lihong V. Wang

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 932304 (2015) https://doi.org/10.1117/12.2076684
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We developed a handheld photoacoustic microscope (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 mm and 3.3 mm thicknesses can be successfully detected in phantom and in vivo experiments, respectively. With its deep melanoma imaging ability and novel handheld design, this system is promising for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.

Citation Download Citation

Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, and Lihong V. Wang "In vivo melanoma depth detection by a handheld photoacoustic microscope", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932304 (11 March 2015); https://doi.org/10.1117/12.2076684

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