High-frequency photoacoustic imaging of erythrocyte aggregation and oxygen saturation: probing hemodynamic relations under pulsatile blood flow

Tae-Hoon Bok; Eno Hysi; Michael C. Kolios

doi:10.1117/12.2076650

11 March 2015 High-frequency photoacoustic imaging of erythrocyte aggregation and oxygen saturation: probing hemodynamic relations under pulsatile blood flow

Tae-Hoon Bok, Eno Hysi, Michael C. Kolios

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93231Q (2015) https://doi.org/10.1117/12.2076650
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In this paper, we investigate the feasibility of high-frequency photoacoustic (PA) imaging to study the shear rate dependent relationship between red blood cell (RBC) aggregation and oxygen saturation (SO₂) in a simulated blood flow system. The PA signal amplitude increased during the formation of aggregates and cyclically varied at intervals corresponding to the beat rate (30, 60, 120, 180 and 240 bpm) for all optical wavelengths of illumination (750 and 850 nm).The SO₂ also cyclically varied in phase with the PA signal amplitude for all beat rates. In addition, the mean blood flow velocity cyclically varied at the same interval of beat rate, and the shear rate (i.e. the radial gradient of flow velocity) also cyclically varied. On the other hand, the phase of the cyclic variation in the shear rate was reversed compared to that in the PA signal amplitude. This study indicates that RBC aggregation induced by periodic changes in the shear rate can be correlated with the SO₂ under pulsatile blood flow. Furthermore, PA imaging of flowing blood may be capable of providing a new biomarker for the clinical application in terms of monitoring blood viscosity, oxygen delivery and their correlation.

Citation Download Citation

Tae-Hoon Bok, Eno Hysi, and Michael C. Kolios "High-frequency photoacoustic imaging of erythrocyte aggregation and oxygen saturation: probing hemodynamic relations under pulsatile blood flow", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231Q (11 March 2015); https://doi.org/10.1117/12.2076650

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