The influence of cellular uptake on the photostability and photoacoustic conversion efficiency of gold nanorods

Lucia Cavigli; Fulvio Ratto; Francesca Tatini; Paolo Matteini; Alberto Cini; Ilaria Giovannelli; Marella de Angelis; Francesca Rossi; Sonia Centi; Roberto Pini

doi:10.1117/12.2077632

11 March 2015 The influence of cellular uptake on gold nanorods photostability and photoacoustic conversion efficiency

Lucia Cavigli, Fulvio Ratto, Francesca Tatini, Paolo Matteini, Alberto Cini, Ilaria Giovannelli, Marella de Angelis, Francesca Rossi, Sonia Centi, Roberto Pini

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 932346 (2015) https://doi.org/10.1117/12.2077632
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Their intense optical absorbance in the near-infrared window and chemical versatility make gold nanorods attractive for biomedical applications, such as photothermal therapies and photoacoustic imaging. However, their limited photostability remains a drawback of practical concern. In fact, when gold nanorods are irradiated with nanosecond laser pulses in resonance with their plasmon oscillations, there may occur reshaping into spherical particles or even fragmentation at higher optical fluences, which cause substantial modifications of their optical features with a loss of photoacoustic conversion efficiency. In this contribution, we focus on how the gold nanorods photostability is affected when these particles are modified for cellular uptake, by investigating their stability and photoacoustic conversion efficiency under near infrared pulsed irradiation at different laser fluences.

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Lucia Cavigli, Fulvio Ratto, Francesca Tatini, Paolo Matteini, Alberto Cini, Ilaria Giovannelli, Marella de Angelis, Francesca Rossi, Sonia Centi, and Roberto Pini "The influence of cellular uptake on gold nanorods photostability and photoacoustic conversion efficiency", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932346 (11 March 2015); https://doi.org/10.1117/12.2077632

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