Advanced laser systems for photoacoustic imaging

Marc Klosner; Ashwin Sampathkumar; Gary Chan; Chunbai Wu; Daniel Gross; Donald F. Heller

doi:10.1117/12.2077780

11 March 2015 Advanced laser systems for photoacoustic imaging

Marc Klosner, Ashwin Sampathkumar, Gary Chan, Chunbai Wu, Daniel Gross, Donald F. Heller

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 932349 (2015) https://doi.org/10.1117/12.2077780
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We describe the ongoing development of laser systems for advanced photoacoustic imaging (PAI). We discuss the characteristics of these laser systems and their particular benefits for soft tissue imaging and next-generation breast cancer diagnostics. We provide an overview of laser performance and compare this with other laser systems that have been used for early-stage development of PAI. These advanced systems feature higher pulse energy output at clinically relevant repetition rates, as well as a novel wavelength-cycling output pulse format. Wavelength cycling provides pulse sequences for which the output repeatedly alternates between two wavelengths that provide differential imaging. This capability improves co-registration of captured differential images. We present imaging results of phantoms obtained with a commercial ultrasound detector system and a wavelength-cycling laser source providing ~500 mJ/pulse at 755 and 797 nm, operating at 25 Hz. The results include photoacoustic images and corresponding pulse-echo data from a tissue mimicking phantom containing inclusions, simulating tumors in the breast. We discuss the application of these systems to the contrast-enhanced detection of various tissue types and tumors.

Citation Download Citation

Marc Klosner, Ashwin Sampathkumar, Gary Chan, Chunbai Wu, Daniel Gross, and Donald F. Heller "Advanced laser systems for photoacoustic imaging", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932349 (11 March 2015); https://doi.org/10.1117/12.2077780

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available