Photoacoustic tomography of the human finger: towards the assessment of inflammatory joint diseases

P. van Es; S. K. Biswas; Hein J. Bernelot Moens; W. Steenbergen; Srirang Manohar

doi:10.1117/12.2078676

11 March 2015 Photoacoustic tomography of the human finger: towards the assessment of inflammatory joint diseases

P. van Es, S. K. Biswas, Hein J. Bernelot Moens, W. Steenbergen, Srirang Manohar

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93234Q (2015) https://doi.org/10.1117/12.2078676
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Inflammatory arthritis is often manifested in finger joints. The growth of new or withdrawal of old blood vessels can be a sensitive marker for these diseases. Photoacoustic (PA) imaging has great potential in this respect since it allows the sensitive and highly resolved visualization of blood. We systematically investigated PA imaging of finger vasculature in healthy volunteers using a newly developed PA tomographic system. We present the PA results which show excellent detail of the vasculature. Vessels with diameters ranging between 100 μm and 1.5 mm are visible along with details of the skin, including the epidermis and the subpapillary plexus. The focus of all the studies is at the proximal and distal interphalangeal joints, and in the context of ultimately visualizing the inflamed synovial membrane in patients. This work is important in laying the foundation for detailed research into PA imaging of the phalangeal vasculature in patients suffering from rheumatoid arthritis.

Citation Download Citation

P. van Es, S. K. Biswas, Hein J. Bernelot Moens, W. Steenbergen, and Srirang Manohar "Photoacoustic tomography of the human finger: towards the assessment of inflammatory joint diseases", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93234Q (11 March 2015); https://doi.org/10.1117/12.2078676

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available