Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model

Xiaojie Wang; Lei Shi; Qingfeng Tu; Hongwei Wang; Haiyan Zhang; Peiru Wang; Linglin Zhang; Zheng Huang; Xiuli Wang; Feng Zhao; Hansen Luan

doi:10.1117/12.2077939

9 March 2015 Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model

Xiaojie Wang, Lei Shi, Qingfeng Tu, Hongwei Wang, Haiyan Zhang, Peiru Wang, Linglin Zhang, Zheng Huang, Xiuli Wang, Feng Zhao, Hansen Luan

Author Affiliations +

Proceedings Volume 9324, Biophotonics and Immune Responses X; 93240U (2015) https://doi.org/10.1117/12.2077939
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted ALA delivery for topical photodynamic therapy (PDT) of cutaneous SCC.

Methods: UV-induced cutaneous SCCs were established in hairless mice. ALA loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NPs-induced protoporphyrin IX (PpIX) fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined.

Results: PLGA NPs could enhance PpIX production in SCC. ALA PLGA NP mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC.

Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.

Citation Download Citation

Xiaojie Wang, Lei Shi, Qingfeng Tu, Hongwei Wang, Haiyan Zhang, Peiru Wang, Linglin Zhang, Zheng Huang, Xiuli Wang, Feng Zhao, and Hansen Luan "Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model", Proc. SPIE 9324, Biophotonics and Immune Responses X, 93240U (9 March 2015); https://doi.org/10.1117/12.2077939

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available