Fabrication of anatomically tapered foveal pits for retinal phantoms for optical coherence tomography

Gary C. F. Lee; Gennifer T. Smith; Monica Agrawal; Audrey K. Ellerbee

doi:10.1117/12.2079730

6 March 2015 Fabrication of anatomically tapered foveal pits for retinal phantoms for optical coherence tomography

Gary C. F. Lee, Gennifer T. Smith, Monica Agrawal, Audrey K. Ellerbee

Proceedings Volume 9325, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII; 932506 (2015) https://doi.org/10.1117/12.2079730
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Optical Coherence Tomography (OCT) has become a standard tool for diagnosing retinal disease in many ophthalmology clinics. Nonetheless, the technical and clinical research communities still lack a standardized phantom that could aid in evaluating and normalizing the various scan protocols and OCT machines employed at different institutions. Existing retinal phantoms designed for OCT imaging mimic some important features of the retina, such as the thickness and scattering properties of its many layers. However, the morphology of the foveal pit and the visible tapering of the retinal layers underlying the surface surrounding the pit remains a challenge to replicate in current phantoms. Recent attempts at creating a realistic foveal pit include molding, ablation and laser etching but have not proved sufficient to replicate this particular anatomical feature. In this work, we demonstrate a new fabrication procedure that is capable of replicating the tapered appearance of the retinal layers near the foveal pit using a combination of spin-coating and replica molding. The ability to create an anatomically correct foveal pit will allow for a new phantom better suited for intra- and inter-system evaluation and for improved testing of retinal segmentation algorithms.

Citation Download Citation

Gary C. F. Lee, Gennifer T. Smith, Monica Agrawal, and Audrey K. Ellerbee "Fabrication of anatomically tapered foveal pits for retinal phantoms for optical coherence tomography", Proc. SPIE 9325, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII, 932506 (6 March 2015); https://doi.org/10.1117/12.2079730

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KEYWORDS

Optical coherence tomography

Glasses

Silicon

Titanium dioxide

Semiconducting wafers

Scattering

Tissues

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