Development of an endoluminal high-intensity ultrasound applicator for image-guided thermal therapy of pancreatic tumors

Matthew S. Adams; Serena J. Scott; Vasant A. Salgaonkar; Peter D. Jones; Juan C. Plata-Camargo; Graham Sommer M.D.; Chris J. Diederich

doi:10.1117/12.2078841

11 March 2015 Development of an endoluminal high-intensity ultrasound applicator for image-guided thermal therapy of pancreatic tumors

Matthew S. Adams, Serena J. Scott, Vasant A. Salgaonkar, Peter D. Jones, Juan C. Plata-Camargo, Graham Sommer M.D., Chris J. Diederich

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Proceedings Volume 9326, Energy-based Treatment of Tissue and Assessment VIII; 93260F (2015) https://doi.org/10.1117/12.2078841
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

An ultrasound applicator for endoluminal thermal therapy of pancreatic tumors has been introduced and evaluated through acoustic/biothermal simulations and ex vivo experimental investigations. Endoluminal therapeutic ultrasound constitutes a minimally invasive conformal therapy and is compatible with ultrasound or MR-based image guidance. The applicator would be placed in the stomach or duodenal lumen, and sonication would be performed through the luminal wall into the tumor, with concurrent water cooling of the wall tissue to prevent its thermal injury. A finite-element (FEM) 3D acoustic and biothermal model was implemented for theoretical analysis of the approach. Parametric studies over transducer geometries and frequencies revealed that operating frequencies within 1-3 MHz maximize penetration depth and lesion volume while sparing damage to the luminal wall. Patient-specific FEM models of pancreatic head tumors were generated and used to assess the feasibility of performing endoluminal ultrasound thermal ablation and hyperthermia of pancreatic tumors. Results indicated over 80% of the volume of small tumors (~2 cm diameter) within 35 mm of the duodenum could be safely ablated in under 30 minutes or elevated to hyperthermic temperatures at steady-state. Approximately 60% of a large tumor (~5 cm diameter) model could be safely ablated by considering multiple positions of the applicator along the length of the duodenum to increase coverage. Prototype applicators containing two 3.2 MHz planar transducers were fabricated and evaluated in ex vivo porcine carcass heating experiments under MR temperature imaging (MRTI) guidance. The applicator was positioned in the stomach adjacent to the pancreas, and sonications were performed for 10 min at 5 W/cm² applied intensity. MRTI indicated over 40⁰C temperature rise in pancreatic tissue with heating penetration extending 3 cm from the luminal wall.

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Matthew S. Adams, Serena J. Scott, Vasant A. Salgaonkar, Peter D. Jones, Juan C. Plata-Camargo, Graham Sommer M.D., and Chris J. Diederich "Development of an endoluminal high-intensity ultrasound applicator for image-guided thermal therapy of pancreatic tumors", Proc. SPIE 9326, Energy-based Treatment of Tissue and Assessment VIII, 93260F (11 March 2015); https://doi.org/10.1117/12.2078841

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KEYWORDS

Tumors

Transducers

Ultrasonography

Tissues

3D modeling

Pancreas

Head

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