In vivo optical elastography: stress and strain imaging of human skin lesions

Shaghayegh Es'haghian; Peijun Gong; Kelsey M. Kennedy; Philip Wijesinghe; David D. Sampson; Robert A. McLaughlin; Brendan F. Kennedy

doi:10.1117/12.2078706

6 March 2015 In vivo optical elastography: stress and strain imaging of human skin lesions

Shaghayegh Es'haghian, Peijun Gong, Kelsey M. Kennedy, Philip Wijesinghe, David D. Sampson, Robert A. McLaughlin, Brendan F. Kennedy

Author Affiliations +

Proceedings Volume 9327, Optical Elastography and Tissue Biomechanics II; 93270C (2015) https://doi.org/10.1117/12.2078706
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Probing the mechanical properties of skin at high resolution could aid in the assessment of skin pathologies by, for example, detecting the extent of cancerous skin lesions and assessing pathology in burn scars. Here, we present two elastography techniques based on optical coherence tomography (OCT) to probe the local mechanical properties of skin. The first technique, optical palpation, is a high-resolution tactile imaging technique, which uses a complaint silicone layer positioned on the tissue surface to measure spatially-resolved stress imparted by compressive loading. We assess the performance of optical palpation, using a handheld imaging probe on a skin-mimicking phantom, and demonstrate its use on human skin. The second technique is a strain imaging technique, phase-sensitive compression OCE that maps depth-resolved mechanical variations within skin. We show preliminary results of in vivo phase-sensitive compression OCE on a human skin lesion.

Citation Download Citation

Shaghayegh Es'haghian, Peijun Gong, Kelsey M. Kennedy, Philip Wijesinghe, David D. Sampson, Robert A. McLaughlin, and Brendan F. Kennedy "In vivo optical elastography: stress and strain imaging of human skin lesions", Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270C (6 March 2015); https://doi.org/10.1117/12.2078706

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