Assessment of the biomechanical properties of porcine cornea after UV cross-linking at different intraocular pressures

Jiasong Li; Manmohan Singh; Srilatha Vantipalli; Zhaolong Han; Chih-Hao Liu; Michael D. Twa; Kirill V. Larin

doi:10.1117/12.2078328

6 March 2015 Assessment of the biomechanical properties of porcine cornea after UV cross-linking at different intraocular pressures

Jiasong Li, Manmohan Singh, Srilatha Vantipalli, Zhaolong Han, Chih-Hao Liu, Michael D. Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 9327, Optical Elastography and Tissue Biomechanics II; 93270Z (2015) https://doi.org/10.1117/12.2078328
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In this study we demonstrate the use of phase-stabilized swept-source optical coherence elastography (PhS-SSOCE) to assess the biomechanical properties of porcine corneas before and after collagen cross-linking (CXL) at different intraocular pressures by measuring the velocity of an air-pulse induced elastic wave and recovery process rate of an air-pulse induced deformation. Young’s moduli were estimated by two different methods: the shear wave equation and a newly developed elasticity reconstruction model. The results show that the corneas became stiffer after the CXL treatment, as evidenced by the increased elastic wave velocity and recovery process rate and greater Young’s modulus. This non-contact and noninvasive measurement technique utilizes minimal force for excitation (deformation less than 10 μm in amplitude) of the tissue. Thus, it can be potentially used to study the biomechanical properties of ocular and other delicate tissues.

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Jiasong Li, Manmohan Singh, Srilatha Vantipalli, Zhaolong Han, Chih-Hao Liu, Michael D. Twa, and Kirill V. Larin "Assessment of the biomechanical properties of porcine cornea after UV cross-linking at different intraocular pressures", Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270Z (6 March 2015); https://doi.org/10.1117/12.2078328

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