Probing axial orientation of collagen fibers with Brillouin microspectroscopy

Zhaokai Meng; Vladislav V. Yakovlev

doi:10.1117/12.2079702

27 March 2015 Probing axial orientation of collagen fibers with Brillouin microspectroscopy

Zhaokai Meng, Vladislav V. Yakovlev

Proceedings Volume 9330, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXII; 93301Q (2015) https://doi.org/10.1117/12.2079702
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Collagen is an important structural component in many biological tissues including bone, teeth, skin, and vascular endothelial layer. Its fibrillar arrangement can produce tissues with distinct anisotropies and is responsible for its unique elastic properties. However, current methods of retrieving orientation of those fibers show low sensitivity to the out-of-plane orientations. In this report, we employed Brillouin microspectroscopy to probe the local sound velocity, which, in its turn, is found to have a strong correlation to the local fibrillar arrangements.

Citation Download Citation

Zhaokai Meng and Vladislav V. Yakovlev "Probing axial orientation of collagen fibers with Brillouin microspectroscopy", Proc. SPIE 9330, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXII, 93301Q (27 March 2015); https://doi.org/10.1117/12.2079702

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