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11 March 2015 Nuclear dynamics in metastatic cells studied by quantitative phase imaging
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Proceedings Volume 9336, Quantitative Phase Imaging; 93361Q (2015)
Event: SPIE BiOS, 2015, San Francisco, California, United States
We used a new quantitative high spatiotemporal resolution phase imaging tool to explore the nuclear structure and dynamics of individual cells. We used a novel analysis tool to quantify the diffusion outside and inside the nucleus of live cells. We also obtained information about the nuclear spatio temporal mass density in metastatic cells. The results indicate that in the cytoplasm, the intracellular transport is mainly active (direct, deterministic), while inside the nucleus it is both active and passive (diffusive, random). We calculated the standard deviation of velocities in active transport and the diffusion coefficient for passive transport.
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Silvia Ceballos, Mikhail Kandel, Shamira Sridharan, Freddy Monroy, and Gabriel Popescu "Nuclear dynamics in metastatic cells studied by quantitative phase imaging", Proc. SPIE 9336, Quantitative Phase Imaging, 93361Q (11 March 2015);

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