A multimodal imaging agent for intrinsic surface enhanced Raman scattering of biological tissue

C. B. Pohling; J. L. Campbell; Timothy A. Larson; S. S. Gambhir M.D.

doi:10.1117/12.2077890

11 March 2015 A multimodal imaging agent for intrinsic surface enhanced Raman scattering of biological tissue

C. B. Pohling, J. L. Campbell, Timothy A. Larson, S. S. Gambhir M.D.

Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 93400A (2015) https://doi.org/10.1117/12.2077890
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Raman imaging is an optical method that provides chemo-selective contrast, microscopic resolution and multiplexing capability. Medical applications, however, still suffer from weak signals and resulting long acquisition times. Plasmon resonance effects can drastically increase signals for Surface Enhanced Raman Scattering (SERS). Here, we present concepts towards an ideal, multimodal SERS agent for medical applications. Enhancement of intrinsic spectra of biological tissue is combined with contrast in Photoacoustic- and Magnetic Resonance Tomography, making this imaging agent highly promising for clinical radiology.

Citation Download Citation

C. B. Pohling, J. L. Campbell, Timothy A. Larson, and S. S. Gambhir M.D. "A multimodal imaging agent for intrinsic surface enhanced Raman scattering of biological tissue", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 93400A (11 March 2015); https://doi.org/10.1117/12.2077890

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KEYWORDS

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Raman spectroscopy

Gold

Surface enhanced Raman spectroscopy

Magnetic resonance imaging

Molecules

Nanoparticles

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