Small animal lung imaging with an in-line X-ray phase contrast benchtop system

A. B. Garson III; S. Gunsten; H. Guan; S. Vasireddi; S. Brody; M. A. Anastasio

doi:10.1117/12.2082898

18 March 2015 Small animal lung imaging with an in-line X-ray phase contrast benchtop system

A. B. Garson III, S. Gunsten, H. Guan, S. Vasireddi, S. Brody, M. A. Anastasio

Author Affiliations +

Proceedings Volume 9412, Medical Imaging 2015: Physics of Medical Imaging; 94120L (2015) https://doi.org/10.1117/12.2082898
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

We present the results from a benchtop X-ray phase-contrast (XPC) method for lung imaging that represents a paradigm shift in the way small animal lung imaging is performed. In our method, information regarding airway microstructure that is encoded within speckle texture of a single XPC radiograph is decoded to spatially resolve changes in lung properties such as microstructure sizes, air volumes, and compliance, to name a few. Such functional information cannot be derived from conventional lung radiography or any other 2D imaging modality. By computing these images at different time points within a breathing cycle, dynamic functional imaging can be potentially achieved without the need for tomography.

Citation Download Citation

A. B. Garson III, S. Gunsten, H. Guan, S. Vasireddi, S. Brody, and M. A. Anastasio "Small animal lung imaging with an in-line X-ray phase contrast benchtop system", Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94120L (18 March 2015); https://doi.org/10.1117/12.2082898

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