X-ray attenuation of adipose breast tissue: in-vitro and in-vivo measurements using spectral imaging

Erik Fredenberg; Klaus Erhard; Karl Berggren; David R Dance; Kenneth C. Young; Björn Cederström; Henrik Johansson; Mats Lundqvist; Elin Moa; Hanno Homan; Paula Willsher; Fleur Kilburn-Toppin; Matthew Wallis

doi:10.1117/12.2081747

18 March 2015 X-ray attenuation of adipose breast tissue: in-vitro and in-vivo measurements using spectral imaging

Erik Fredenberg, Klaus Erhard, Karl Berggren, David R Dance, Kenneth C. Young, Björn Cederström, Henrik Johansson, Mats Lundqvist, Elin Moa, Hanno Homan, Paula Willsher, Fleur Kilburn-Toppin, Matthew Wallis

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Proceedings Volume 9412, Medical Imaging 2015: Physics of Medical Imaging; 94121U (2015) https://doi.org/10.1117/12.2081747
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

The development of new x-ray imaging techniques often requires prior knowledge of tissue attenuation, but the sources of such information are sparse. We have measured the attenuation of adipose breast tissue using spectral imaging, in vitro and in vivo. For the in-vitro measurement, fixed samples of adipose breast tissue were imaged on a spectral mammography system, and the energy-dependent x-ray attenuation was measured in terms of equivalent thicknesses of aluminum and poly-methyl methacrylate (PMMA). For the in-vivo measurement, a similar procedure was applied on a number of spectral screening mammograms. The results of the two measurements agreed well and were consistent with published attenuation data and with measurements on tissue-equivalent material.

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Erik Fredenberg, Klaus Erhard, Karl Berggren, David R Dance, Kenneth C. Young, Björn Cederström, Henrik Johansson, Mats Lundqvist, Elin Moa, Hanno Homan, Paula Willsher, Fleur Kilburn-Toppin, and Matthew Wallis "X-ray attenuation of adipose breast tissue: in-vitro and in-vivo measurements using spectral imaging", Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94121U (18 March 2015); https://doi.org/10.1117/12.2081747

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KEYWORDS

Tissues

Signal attenuation

In vitro testing

Breast

Aluminum

In vivo imaging

X-rays

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