Computational analysis of PET by AIBL (CapAIBL): a cloud-based processing pipeline for the quantification of PET images

Pierrick Bourgeat; Vincent Dore; Jurgen Fripp; Victor L. Villemagne; Chris C. Rowe; Olivier Salvado

doi:10.1117/12.2082492

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20 March 2015 Computational analysis of PET by AIBL (CapAIBL): a cloud-based processing pipeline for the quantification of PET images

Pierrick Bourgeat, Vincent Dore, Jurgen Fripp, Victor L. Villemagne, Chris C. Rowe, Olivier Salvado

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Proceedings Volume 9413, Medical Imaging 2015: Image Processing; 94132V (2015) https://doi.org/10.1117/12.2082492
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

With the advances of PET tracers for β-Amyloid (Aβ) detection in neurodegenerative diseases, automated quantification methods are desirable. For clinical use, there is a great need for PET-only quantification method, as MR images are not always available. In this paper, we validate a previously developed PET-only quantification method against MR-based quantification using 6 tracers: ¹⁸F-Florbetaben (N=148), ¹⁸F-Florbetapir (N=171), ¹⁸F-NAV4694 (N=47), ¹⁸F-Flutemetamol (N=180), ¹¹C-PiB (N=381) and ¹⁸F-FDG (N=34). The results show an overall mean absolute percentage error of less than 5% for each tracer. The method has been implemented as a remote service called CapAIBL (http://milxcloud.csiro.au/capaibl). PET images are uploaded to a cloud platform where they are spatially normalised to a standard template and quantified. A report containing global as well as local quantification, along with surface projection of the β-Amyloid deposition is automatically generated at the end of the pipeline and emailed to the user.

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Pierrick Bourgeat, Vincent Dore, Jurgen Fripp, Victor L. Villemagne, Chris C. Rowe, and Olivier Salvado "Computational analysis of PET by AIBL (CapAIBL): a cloud-based processing pipeline for the quantification of PET images", Proc. SPIE 9413, Medical Imaging 2015: Image Processing, 94132V (20 March 2015); https://doi.org/10.1117/12.2082492

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