The evaluation of multi-structure, multi-atlas pelvic anatomy features in a prostate MR lymphography CAD system

M. Meijs; O. Debats; H. Huisman

doi:10.1117/12.2082708

20 March 2015 The evaluation of multi-structure, multi-atlas pelvic anatomy features in a prostate MR lymphography CAD system

M. Meijs, O. Debats, H. Huisman

Author Affiliations +

Proceedings Volume 9414, Medical Imaging 2015: Computer-Aided Diagnosis; 94140T (2015) https://doi.org/10.1117/12.2082708
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

In prostate cancer, the detection of metastatic lymph nodes indicates progression from localized disease to metastasized cancer. The detection of positive lymph nodes is, however, a complex and time consuming task for experienced radiologists. Assistance of a two-stage Computer-Aided Detection (CAD) system in MR Lymphography (MRL) is not yet feasible due to the large number of false positives in the first stage of the system. By introducing a multi-structure, multi-atlas segmentation, using an affine transformation followed by a B-spline transformation for registration, the organ location is given by a mean density probability map. The atlas segmentation is semi-automatically drawn with ITK-SNAP, using Active Contour Segmentation. Each anatomic structure is identified by a label number. Registration is performed using Elastix, using Mutual Information and an Adaptive Stochastic Gradient optimization. The dataset consists of the MRL scans of ten patients, with lymph nodes manually annotated in consensus by two expert readers. The feature map of the CAD system consists of the Multi-Atlas and various other features (e.g. Normalized Intensity and multi-scale Blobness). The voxel-based Gentleboost classifier is evaluated using ROC analysis with cross validation. We show in a set of 10 studies that adding multi-structure, multi-atlas anatomical structure likelihood features improves the quality of the lymph node voxel likelihood map. Multiple structure anatomy maps may thus make MRL CAD more feasible.

Citation Download Citation

M. Meijs, O. Debats, and H. Huisman "The evaluation of multi-structure, multi-atlas pelvic anatomy features in a prostate MR lymphography CAD system", Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 94140T (20 March 2015); https://doi.org/10.1117/12.2082708

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available