Computer-based assessment of right ventricular regional ejection fraction in patients with repaired Tetralogy of Fallot

S.-K. Teo; S. T. Wong; M. L. Tan; Y. Su; L. Zhong; Ru-San Tan

doi:10.1117/12.2081839

20 March 2015 Computer-based assessment of right ventricular regional ejection fraction in patients with repaired Tetralogy of Fallot

S.-K. Teo, S. T. Wong, M. L. Tan, Y. Su, L. Zhong, Ru-San Tan

Author Affiliations +

Proceedings Volume 9414, Medical Imaging 2015: Computer-Aided Diagnosis; 941431 (2015) https://doi.org/10.1117/12.2081839
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

After surgical repair for Tetralogy of Fallot (TOF), most patients experience long-term complications as the right ventricle (RV) undergoes progressive remodeling that eventually affect heart functions. Thus, post-repair surgery is required to prevent further deterioration of RV functions that may result in malignant ventricular arrhythmias and mortality. The timing of such post-repair surgery therefore depends crucially on the quantitative assessment of the RV functions. Current clinical indices for such functional assessment measure global properties such as RV volumes and ejection fraction. However, these indices are less than ideal as regional variations and anomalies are obscured. Therefore, we sought to (i) develop a quantitative method to assess RV regional function using regional ejection fraction (REF) based on a 13-segment model, and (ii) evaluate the effectiveness of REF in discriminating 6 repaired TOF patients and 6 normal control based on cardiac magnetic resonance (CMR) imaging. We observed that the REF for the individual segments in the patient group is significantly lower compared to the control group (P < 0.05 using a 2-tail student t-test). In addition, we also observed that the aggregated REF at the basal, mid-cavity and apical regions for the patient group is significantly lower compared to the control group (P < 0.001 using a 2-tail student t-test). The results suggest that REF could potentially be used as a quantitative index for assessing RV regional functions. The computational time per data set is approximately 60 seconds, which demonstrates our method’s clinical potential as a real-time cardiac assessment tool.

Citation Download Citation

S.-K. Teo, S. T. Wong, M. L. Tan, Y. Su, L. Zhong, and Ru-San Tan "Computer-based assessment of right ventricular regional ejection fraction in patients with repaired Tetralogy of Fallot", Proc. SPIE 9414, Medical Imaging 2015: Computer-Aided Diagnosis, 941431 (20 March 2015); https://doi.org/10.1117/12.2081839

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KEYWORDS

Image segmentation

Heart

Cardiovascular magnetic resonance imaging

Surgery

Magnetic resonance imaging

Magnetism

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