Automated pulmonary lobar ventilation measurements using volume-matched thoracic CT and MRI

F. Guo; S. Svenningsen; E. Bluemke; Martin Rajchl; Jing Yuan; Aaron Fenster; Grace Parraga

doi:10.1117/12.2076398

17 March 2015 Automated pulmonary lobar ventilation measurements using volume-matched thoracic CT and MRI

F. Guo, S. Svenningsen, E. Bluemke, Martin Rajchl, Jing Yuan, Aaron Fenster, Grace Parraga

Proceedings Volume 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging; 941717 (2015) https://doi.org/10.1117/12.2076398
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

Objectives: To develop and evaluate an automated registration and segmentation pipeline for regional lobar pulmonary structure-function measurements, using volume-matched thoracic CT and MRI in order to guide therapy. Methods: Ten subjects underwent pulmonary function tests and volume-matched ¹H and ³He MRI and thoracic CT during a single 2-hr visit. CT was registered to ¹H MRI using an affine method that incorporated block-matching and this was followed by a deformable step using free-form deformation. The resultant deformation field was used to deform the associated CT lobe mask that was generated using commercial software. ³He-¹H image registration used the same two-step registration method and ³He ventilation was segmented using hierarchical k-means clustering. Whole lung and lobar ³He ventilation and ventilation defect percent (VDP) were generated by mapping ventilation defects to CT-defined whole lung and lobe volumes. Target CT-³He registration accuracy was evaluated using region- , surface distance- and volume-based metrics. Automated whole lung and lobar VDP was compared with semi-automated and manual results using paired t-tests. Results: The proposed pipeline yielded regional spatial agreement of 88.0±0.9% and surface distance error of 3.9±0.5 mm. Automated and manual whole lung and lobar ventilation and VDP were not significantly different and they were significantly correlated (r = 0.77, p < 0.0001). Conclusion: The proposed automated pipeline can be used to generate regional pulmonary structural-functional maps with high accuracy and robustness, providing an important tool for image-guided pulmonary interventions.

Citation Download Citation

F. Guo, S. Svenningsen, E. Bluemke, Martin Rajchl, Jing Yuan, Aaron Fenster, and Grace Parraga "Automated pulmonary lobar ventilation measurements using volume-matched thoracic CT and MRI", Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 941717 (17 March 2015); https://doi.org/10.1117/12.2076398

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