Modeling and simulation of the multiphase flow involving magnetophoresis-based microfluidic systems

Saud A. Khashan; Anas Alazzam; Bobby Mathew

doi:10.1117/12.2178657

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21 May 2015 Modeling and simulation of the multiphase flow involving magnetophoresis-based microfluidic systems

Saud A. Khashan, Anas Alazzam, Bobby Mathew

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Proceedings Volume 9517, Smart Sensors, Actuators, and MEMS VII; and Cyber Physical Systems; 951728 (2015) https://doi.org/10.1117/12.2178657
Event: SPIE Microtechnologies, 2015, Barcelona, Spain

Abstract

In this study, we use the Lagrangian-Eulerian model, usually termed as Discrete Particle Model(DPM), and the Eulerian mixture model to numerically simulate the magnetophoresis-based separation of magnetic beads in a microfluidic system. The separation is based on High Gradient Magnetic Separation (HGMS) principle. A comparative assessment of both computational models was conducted. Mixture model provides a solution similar to that obtained using the DPM but with reduced computational time. However, the fidelity of mixture model can be attained only by the proper modeling of the slip velocity between the particle and the carrier fluid. For both of DPM and mixture approaches, the appropriate constitutive physics models for drag, lift, slip were resolved.

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Saud A. Khashan, Anas Alazzam, and Bobby Mathew "Modeling and simulation of the multiphase flow involving magnetophoresis-based microfluidic systems", Proc. SPIE 9517, Smart Sensors, Actuators, and MEMS VII; and Cyber Physical Systems, 951728 (21 May 2015); https://doi.org/10.1117/12.2178657

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