High-throughput microfluidic device for rare cell isolation

Daniel Yang; Serena Leong; Andy Lei; Lydia L. Sohn

doi:10.1117/12.2178613

1 June 2015 High-throughput microfluidic device for rare cell isolation

Daniel Yang, Serena Leong, Andy Lei, Lydia L. Sohn

Proceedings Volume 9518, Bio-MEMS and Medical Microdevices II; 95180E (2015) https://doi.org/10.1117/12.2178613
Event: SPIE Microtechnologies, 2015, Barcelona, Spain

Abstract

Enumerating and analyzing circulating tumor cells (CTCs)—cells that have been shed from primary solid tumors—can potentially be used to determine patient prognosis and track the progression of disease. There is a great challenge to create an effective platform that can isolate these cells, as they are extremely rare: only 1-10 CTCs are present in a 7.5mL of a cancer patient’s peripheral blood. We have developed a novel microfluidic system that can isolate CTC populations label free. Our system consists of a multistage separator that employs inertial migration to sort cells based on size. We demonstrate the feasibility of our device by sorting colloids that are comparable in size to red blood cells (RBCs) and CTCs.

Citation Download Citation

Daniel Yang, Serena Leong, Andy Lei, and Lydia L. Sohn "High-throughput microfluidic device for rare cell isolation", Proc. SPIE 9518, Bio-MEMS and Medical Microdevices II, 95180E (1 June 2015); https://doi.org/10.1117/12.2178613

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